Systemic GM-CSF recruits effector T cells into the tumor microenvironment in localized prostate cancer

Granulocytic-macrophage colony-stimulating factor (GM-CSF) is used as an adjuvant in cancer vaccine trials and has the potential to enhance antitumor efficacy with immunotherapy; however, its immunologic effects are not fully understood. Here, we report results from a phase 1 study of neoadjuvant GM...

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Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Wei, Xiao X., Chan, Stephen, Kwek, Serena, Lewis, Jera, Dao, Vinh, Zhang, Li, Cooperberg, Matthew R., Ryan, Charles J., Lin, Amy M., Friedlander, Terence W., Rini, Brian, Kane, Christopher, Simko, Jeffry P., Carroll, Peter R., Small, Eric J., Fong, Lawrence
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115633/
https://ncbi.nlm.nih.gov/pubmed/27688020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0042
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