Salinomycin inhibits metastatic colorectal cancer growth and interferes with Wnt/β-catenin signaling in CD133(+) human colorectal cancer cells

BACKGROUND: The polyether antibiotic Salinomycin (Sal) is regarded as an inhibitor of cancer stem cells. Its effectiveness on human colorectal cancer (CRC) cells in vitro has been demonstrated before. The aim of this study was to establish a murine model to investigate the effectiveness of Sal in vi...

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Udgivet i:BMC Cancer
Main Authors: Klose, Johannes, Eissele, Jana, Volz, Claudia, Schmitt, Steffen, Ritter, Alina, Ying, Shen, Schmidt, Thomas, Heger, Ulrike, Schneider, Martin, Ulrich, Alexis
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114842/
https://ncbi.nlm.nih.gov/pubmed/27855654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2879-8
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