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mTOR Inhibitors Rescue Premature Lethality and Attenuate Dysregulation of GABAergic/Glutamatergic Transcription in Murine Succinate Semialdehyde Dehydrogenase Deficiency (SSADHD), a Disorder of GABA Metabolism

Recent studies have identified a role for supraphysiological GABA in the regulation of mTOR (mechanistic target of rapamycin), a protein kinase with pleiotropic roles in cellular development and homeostasis, including integration of growth factors and nutrient sensing, and synaptic input in neurons...

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Foilsithe in:J Inherit Metab Dis
Main Authors: Vogel, Kara R., Ainslie, Garrett R., Gibson, K. Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114712/
https://ncbi.nlm.nih.gov/pubmed/27518770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-016-9959-4
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