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Therapeutic Relevance of mTOR Inhibition in Murine Succinate Semialdehyde Dehydrogenase Deficiency (SSADHD), a Disorder of GABA Metabolism()
Aldehyde dehydrogenase 5a1-deficient (aldh5a1(−/−)) mice, the murine orthologue of human succinic semialdehyde dehydrogenase deficiency (SSADHD), manifest increased GABA (4-aminobutyric acid) that disrupts autophagy, increases mitochondria number, and induces oxidative stress, all mitigated with the...
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| Publicado no: | Biochim Biophys Acta |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5154833/ https://ncbi.nlm.nih.gov/pubmed/27760377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2016.10.009 |
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