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mTOR Inhibitors Rescue Premature Lethality and Attenuate Dysregulation of GABAergic/Glutamatergic Transcription in Murine Succinate Semialdehyde Dehydrogenase Deficiency (SSADHD), a Disorder of GABA Metabolism
Recent studies have identified a role for supraphysiological GABA in the regulation of mTOR (mechanistic target of rapamycin), a protein kinase with pleiotropic roles in cellular development and homeostasis, including integration of growth factors and nutrient sensing, and synaptic input in neurons...
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| Publié dans: | J Inherit Metab Dis |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5114712/ https://ncbi.nlm.nih.gov/pubmed/27518770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-016-9959-4 |
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