Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD

The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies. Using high-throughput screening, we have identified 2-phenyl benzo[d...

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Publicado no:Sci Rep
Main Authors: Price, Kathryn E., Armstrong, Christopher M., Imlay, Leah S., Hodge, Dana M., Pidathala, C., Roberts, Natalie J., Park, Jooyoung, Mikati, Marwa, Sharma, Raman, Lawrenson, Alexandre S., Tolia, Niraj H., Berry, Neil G., O’Neill, Paul M., John, Audrey R. Odom
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114681/
https://ncbi.nlm.nih.gov/pubmed/27857147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36777
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