Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy

Photodynamic therapy (PDT) and diagnosis (PDD) using 5-aminolevulinic acid (ALA) to drive the production of an intracellular photosensitizer, protoporphyrin IX (PpIX), are in common clinical use. However, the tendency to accumulate PpIX is not well understood. Patients with cancer can develop recurr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nakayama, Taku, Otsuka, Shimpei, Kobayashi, Tatsuya, Okajima, Hodaka, Matsumoto, Kentaro, Hagiya, Yuichiro, Inoue, Keiji, Shuin, Taro, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114660/
https://ncbi.nlm.nih.gov/pubmed/27857072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36478
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