CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells

Continuous contact with self-major histocompatibility complex (MHC) ligands is essential for survival of naïve T cells but not memory cells. This surprising finding implies that T cell subsets may vary in their relative T-cell receptor (TCR) sensitivity. Here we show that in CD8(+)T cells TCR sensit...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Cho, Jae-Ho, Kim, Hee-Ok, Ju, Young-Jun, Kye, Yoon-Chul, Lee, Gil-Woo, Lee, Sung-Woo, Yun, Cheol-Heui, Bottini, Nunzio, Webster, Kylie, Goodnow, Christopher C., Surh, Charles D., King, Cecile, Sprent, Jonathan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114568/
https://ncbi.nlm.nih.gov/pubmed/27841348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13373
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