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STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit

N-methyl-D-aspartate receptors (NMDARs) are necessary for the induction of synaptic plasticity and for the consolidation of learning and memory. NMDAR function is tightly regulated by functionally opposed families of kinases and phosphatases. Herein we show that the striatal-enriched protein tyrosin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tian, Meng, Xu, Jian, Lei, Gang, Lombroso, Paul J., Jackson, Michael F., MacDonald, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114553/
https://ncbi.nlm.nih.gov/pubmed/27857196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36684
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