Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells

Hypotonic stress decreased claudin-1 and -2 expression levels in renal tubular epithelial HK-2 and Madin-Darby canine kidney cells. Here, we examined the regulatory mechanism involved in this decrease. The hypotonicity-induced decrease in claudin expression was inhibited by the following: SB202190,...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fujii, Naoko, Matsuo, Yukinobu, Matsunaga, Toshiyuki, Endo, Satoshi, Sakai, Hideki, Yamaguchi, Masahiko, Yamazaki, Yasuhiro, Sugatani, Junko, Ikari, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114426/
https://ncbi.nlm.nih.gov/pubmed/27733684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.728196
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