Synthesis of Highly Selective Submicromolar Microcystin‐Based Inhibitors of Protein Phosphatase (PP)2A over PP1

Research and therapeutic targeting of the phosphoserine/threonine phosphatases PP1 and PP2A is hindered by the lack of selective inhibitors. The microcystin (MC) natural toxins target both phosphatases with equal potency, and their complex synthesis has complicated structure–activity relationship st...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Fontanillo, Miriam, Zemskov, Ivan, Häfner, Maximilian, Uhrig, Ulrike, Salvi, Francesca, Simon, Bernd, Wittmann, Valentin, Köhn, Maja
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113787/
https://ncbi.nlm.nih.gov/pubmed/27723199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201606449
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