Synthesis of Highly Selective Submicromolar Microcystin‐Based Inhibitors of Protein Phosphatase (PP)2A over PP1

Research and therapeutic targeting of the phosphoserine/threonine phosphatases PP1 and PP2A is hindered by the lack of selective inhibitors. The microcystin (MC) natural toxins target both phosphatases with equal potency, and their complex synthesis has complicated structure–activity relationship st...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Fontanillo, Miriam, Zemskov, Ivan, Häfner, Maximilian, Uhrig, Ulrike, Salvi, Francesca, Simon, Bernd, Wittmann, Valentin, Köhn, Maja
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113787/
https://ncbi.nlm.nih.gov/pubmed/27723199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201606449
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