Synthesis of Highly Selective Submicromolar Microcystin‐Based Inhibitors of Protein Phosphatase (PP)2A over PP1

Research and therapeutic targeting of the phosphoserine/threonine phosphatases PP1 and PP2A is hindered by the lack of selective inhibitors. The microcystin (MC) natural toxins target both phosphatases with equal potency, and their complex synthesis has complicated structure–activity relationship st...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Angew Chem Int Ed Engl
Egile Nagusiak: Fontanillo, Miriam, Zemskov, Ivan, Häfner, Maximilian, Uhrig, Ulrike, Salvi, Francesca, Simon, Bernd, Wittmann, Valentin, Köhn, Maja
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2016
Gaiak:
Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113787/
https://ncbi.nlm.nih.gov/pubmed/27723199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201606449
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