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New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis

The nonribosomal peptide synthetases (NRPSs) are one of the most promising resources for the production of new bioactive molecules. The mechanism of NRPS catalysis is based around sequential catalytic domains: these are organized into modules, where each module selects, modifies, and incorporates an...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Kittilä, Tiia, Mollo, Aurelio, Charkoudian, Louise K., Cryle, Max J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113783/
https://ncbi.nlm.nih.gov/pubmed/27435901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201602614
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