Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase

Several studies over the last few decades have shown that antibiotic resistance mechanisms frequently confer a fitness cost and that these costs can be genetically ameliorated by intra- or extragenic second-site mutations, often without loss of resistance. Another, much less studied potential mechan...

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Gepubliceerd in:RNA
Hoofdauteurs: Freihofer, Pietro, Akbergenov, Rashid, Teo, Youjin, Juskeviciene, Reda, Andersson, Dan I., Böttger, Erik C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113204/
https://ncbi.nlm.nih.gov/pubmed/27698071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.057257.116
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