Fast Motions of Key Methyl Groups in Amyloid-β Fibrils

Amyloid-β (Aβ) peptide is the major component of plaques found in Alzheimer’s disease patients. Using solid-state (2)H NMR relaxation performed on selectively deuterated methyl groups, we probed the dynamics in the threefold symmetric and twofold symmetric polymorphs of native Aβ as well as the prot...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biophys J
Prif Awduron: Vugmeyster, Liliya, Ostrovsky, Dmitry, Clark, Matthew A., Falconer, Isaac B., Hoatson, Gina L., Qiang, Wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2016
Pynciau:
Proteins
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113154/
https://ncbi.nlm.nih.gov/pubmed/27851938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.10.001
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