Fast Motions of Key Methyl Groups in Amyloid-β Fibrils

Amyloid-β (Aβ) peptide is the major component of plaques found in Alzheimer’s disease patients. Using solid-state (2)H NMR relaxation performed on selectively deuterated methyl groups, we probed the dynamics in the threefold symmetric and twofold symmetric polymorphs of native Aβ as well as the prot...

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Bibliografiset tiedot
Julkaisussa:Biophys J
Päätekijät: Vugmeyster, Liliya, Ostrovsky, Dmitry, Clark, Matthew A., Falconer, Isaac B., Hoatson, Gina L., Qiang, Wei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Biophysical Society 2016
Aiheet:
Proteins
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113154/
https://ncbi.nlm.nih.gov/pubmed/27851938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.10.001
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