Adenosine Selectively Depletes Alloreactive T Cells to Prevent GVHD While Conserving Immunity to Viruses and Leukemia

Selective depletion (SD) of alloreactive T cells from allogeneic hematopoeitic stem cell transplants to prevent graft-versus-host disease (GVHD) without compromising immune reconstitution and antitumor responses remains a challenge. Here, we demonstrate a novel SD strategy whereby alloreacting T cel...

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Publicat a:Mol Ther
Autors principals: Whitehill, Greg D, Amarnath, Shoba, Muranski, Pawel, Keyvanfar, Keyvan, Battiwalla, Minoo, Barrett, Austin J., Chinnassamy, Dhanalakshmi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113112/
https://ncbi.nlm.nih.gov/pubmed/27401140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.147
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