Targeting T cell Bioenergetics by Modulating P-glycoprotein Selectively Depletes Alloreactive T cells to Prevent GVHD()

T lymphocytes play a central role in many human immunologic disorders including autoimmune and alloimmune diseases. In hematopoietic stem cell transplant, acute graft-versus-host-disease (GVHD) is caused by an attack on the recipient’s tissues from donor allogeneic T cells. Selectively depleting GVH...

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Veröffentlicht in:J Immunol
Hauptverfasser: McIver, Zachariah A., Grayson, Jason M., Coe, Benjamin, Hill, Jacqueline E., Schamerhorn, Gregory A., Ohulchanskyy, Tymish Y., Linder, Michelle K., Davies, Kellie S., Weiner, Roy S., Detty, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992642/
https://ncbi.nlm.nih.gov/pubmed/27456485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402445
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