Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins

The human Na(+)/K(+)-ATPase (NKA) is a plasma membrane ion pump that uses ATP to help maintain the resting potential of all human cells. Inhibition of the NKA leads to cell swelling and death. The results of this investigation show that on cancer cells, the NKA either comes in close proximity to, as...

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Marshall, David J, Harried, Scott S, Murphy, John L, Hall, Chad A, Shekhani, Mohammed S, Pain, Christophe, Lyons, Conner A, Chillemi, Antonella, Malavasi, Fabio, Pearce, Homer L, Thorson, Jon S, Prudent, James R
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112037/
https://ncbi.nlm.nih.gov/pubmed/27434591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.119
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