Pharmacokinetics and Pharmacodynamics of Omarigliptin, a Once‐Weekly Dipeptidyl Peptidase‐4 (DPP‐4) Inhibitor, After Single and Multiple Doses in Healthy Subjects

The pharmacokinetics (PK) and pharmacodynamics (PD) of omarigliptin, a novel once‐weekly DPP‐4 inhibitor, were assessed following single and multiple doses in healthy subjects. Absorption was rapid, and food did not influence single‐dose PK. Accumulation was minimal, and steady state was reached aft...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Krishna, Rajesh, Addy, Carol, Tatosian, Daniel, Glasgow, Xiaoli S., Gendrano III, Isaias Noel, Robberechts, Martine, Haazen, Wouter, de Hoon, J.N., Depré, Marleen, Martucci, Ashley, Peng, Joanna Z., Johnson‐Levonas, Amy O., Wagner, John A., Stoch, S. Aubrey
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111764/
https://ncbi.nlm.nih.gov/pubmed/27225334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.773
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