Pharmacokinetics and Pharmacodynamics of Omarigliptin, a Once‐Weekly Dipeptidyl Peptidase‐4 (DPP‐4) Inhibitor, After Single and Multiple Doses in Healthy Subjects

The pharmacokinetics (PK) and pharmacodynamics (PD) of omarigliptin, a novel once‐weekly DPP‐4 inhibitor, were assessed following single and multiple doses in healthy subjects. Absorption was rapid, and food did not influence single‐dose PK. Accumulation was minimal, and steady state was reached aft...

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Bibliografiset tiedot
Julkaisussa:J Clin Pharmacol
Päätekijät: Krishna, Rajesh, Addy, Carol, Tatosian, Daniel, Glasgow, Xiaoli S., Gendrano III, Isaias Noel, Robberechts, Martine, Haazen, Wouter, de Hoon, J.N., Depré, Marleen, Martucci, Ashley, Peng, Joanna Z., Johnson‐Levonas, Amy O., Wagner, John A., Stoch, S. Aubrey
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2016
Aiheet:
Pharmacokinetics/Pharmacodynamics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111764/
https://ncbi.nlm.nih.gov/pubmed/27225334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.773
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