Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization

Target-blind activity-based screening of molecular libraries is often used to develop first-generation compounds, but subsequent target identification is rate-limiting to developing improved agents with higher specific affinity and lower off-target binding. A fluorescently labeled nerve-binding pept...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Glasgow, Heather L., Whitney, Michael A., Gross, Larry A., Friedman, Beth, Adams, Stephen R., Crisp, Jessica L., Hussain, Timon, Frei, Andreas P., Novy, Karel, Wollscheid, Bernd, Nguyen, Quyen T., Tsien, Roger Y.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111686/
https://ncbi.nlm.nih.gov/pubmed/27791138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611642113
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