Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen

Hepatitis C virus (HCV) is a major cause of liver disease, affecting over 2% of the world’s population. The HCV envelope glycoproteins E1 and E2 mediate viral entry, with E2 being the main target of neutralizing antibody responses. Structural investigations of E2 have produced templates for vaccine...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kong, Leopold, Lee, David E., Kadam, Rameshwar U., Liu, Tong, Giang, Erick, Nieusma, Travis, Garces, Fernando, Tzarum, Netanel, Woods, Virgil L., Ward, Andrew B., Li, Sheng, Wilson, Ian A., Law, Mansun
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111675/
https://ncbi.nlm.nih.gov/pubmed/27791120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609780113
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