Complement inhibition enables tumor delivery of LCMV glycoprotein pseudotyped viruses in the presence of antiviral antibodies

The systemic delivery of therapeutic viruses, such as oncolytic viruses or vaccines, is limited by the generation of neutralizing antibodies. While pseudotyping of rhabdoviruses with the lymphocytic choriomeningitis virus glycoprotein has previously allowed for multiple rounds of delivery in mice, t...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Evgin, Laura, Ilkow, Carolina S, Bourgeois-Daigneault, Marie-Claude, de Souza, Christiano Tanese, Stubbert, Lawton, Huh, Michael S, Jennings, Victoria A, Marguerie, Monique, Acuna, Sergio A, Keller, Brian A, Lefebvre, Charles, Falls, Theresa, Le Boeuf, Fabrice, Auer, Rebecca A, Lambris, John D, McCart, J Andrea, Stojdl, David F, Bell, John C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111574/
https://ncbi.nlm.nih.gov/pubmed/27909702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2016.27
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