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Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells
A peptidase-resistant ABL kinase substrate was developed by identifying protease-susceptible bonds on an ABL substrate peptide and replacing flanking amino acids with non-native amino acids. After an iterative design process, the lead, or designed, peptide X-A possesses a six-fold longer life in a c...
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| Udgivet i: | Analyst |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5111365/ https://ncbi.nlm.nih.gov/pubmed/27704073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6an01378c |
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