Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A

BACKGROUND: The gene PPARGC1A, in particular the Gly482Ser variant (rs8192678), had been proposed to be subject to natural selection, particularly in recent progenitors of extant Polynesian populations. Reasons include high levels of population differentiation and increased frequencies of the derive...

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Veröffentlicht in:BMC Med Genet
Hauptverfasser: Cadzow, Murray, Merriman, Tony R., Boocock, James, Dalbeth, Nicola, Stamp, Lisa K., Black, Michael A., Visscher, Peter M., Wilcox, Phillip L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111290/
https://ncbi.nlm.nih.gov/pubmed/27846814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-016-0341-z
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