Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A

BACKGROUND: The gene PPARGC1A, in particular the Gly482Ser variant (rs8192678), had been proposed to be subject to natural selection, particularly in recent progenitors of extant Polynesian populations. Reasons include high levels of population differentiation and increased frequencies of the derive...

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Bibliographic Details
Published in:BMC Med Genet
Main Authors: Cadzow, Murray, Merriman, Tony R., Boocock, James, Dalbeth, Nicola, Stamp, Lisa K., Black, Michael A., Visscher, Peter M., Wilcox, Phillip L.
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111290/
https://ncbi.nlm.nih.gov/pubmed/27846814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-016-0341-z
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