The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells

Protein phosphatase 2A (PP2A) activity can be enhanced pharmacologically by PP2A-activating drugs (PADs). The sphingosine analog FTY720 is the best known PAD and we have shown that FTY720 represses production of pro-inflammatory cytokines responsible for respiratory disease pathogenesis. Whether its...

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Publicado no:Sci Rep
Principais autores: Rahman, Md. Mostafizur, Prünte, Laura, Lebender, Leonard F., Patel, Brijeshkumar S., Gelissen, Ingrid, Hansbro, Philip M., Morris, Jonathan C., Clark, Andrew R., Verrills, Nicole M., Ammit, Alaina J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110966/
https://ncbi.nlm.nih.gov/pubmed/27849062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37297
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