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Amelioration of proteolipid protein 139–151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms

Copolymer 1 [Cop1, glatiramer acetate, Copaxone, poly(Y,E,A,K)n] is widely used in the treatment of relapsing/remitting multiple sclerosis in which it reduces the frequency of relapses by ≈30%. In the present study, copolymers with modified amino acid compositions (based on the binding motif of myel...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Stern, Joel N. H., Illés, Zsolt, Reddy, Jayagopala, Keskin, Derin B., Sheu, Eric, Fridkis-Hareli, Masha, Nishimura, Hiroyuki, Brosnan, Celia F., Santambrogio, Laura, Kuchroo, Vijay K., Strominger, Jack L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC511046/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15292514/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0403832101
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