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SF2312 is a natural phosphonate inhibitor of Enolase

Despite being critical for energy generation in most forms of life, few if any microbial antibiotics specifically inhibit glycolysis. To develop a specific inhibitor of the glycolytic enzyme Enolase 2 for the treatment of cancers with deletion of Enolase 1, we modeled the synthetic tool compound inh...

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Pubblicato in:Nat Chem Biol
Autori principali: Leonard, Paul G., Satani, Nikunj, Maxwell, David, Lin, Yu-Hsi, Hammoudi, Naima, Peng, Zhenghong, Pisaneschi, Federica, Link, Todd M., Lee, Gilbert R., Sun, Duoli, Prasad, Basvoju A. Bhanu, Di Francesco, Maria Emilia, Czako, Barbara, Asara, John M., Wang, Y. Alan, Bornmann, William, DePinho, Ronald A., Muller, Florian L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110371/
https://ncbi.nlm.nih.gov/pubmed/27723749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2195
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