Kinase regulation of Human MHC Class I Molecule Expression on Cancer Cells

The major histocompatibility complex I (MHC-I) presents antigenic peptides to tumor-specific CD8(+) T cells. The regulation of MHC-I by kinases is largely unstudied, even though many patients with cancer are receiving therapeutic kinase inhibitors. Regulators of cell surface HLA amounts were discove...

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Publicado no:Cancer Immunol Res
Main Authors: Brea, Elliott J., Oh, Claire Y., Manchado, Eusebio, Budhu, Sadna, S.Gejman, Ron, Mo, George, Mondello, Patrizia, Han, James E., Jarvis, Casey A., Ulmert, David, Xiang, Qing, Chang, Aaron Y., Garippa, Ralph J., Merghoub, Taha, Wolchok, Jedd D., Rosen, Neal, Lowe, Scott W., Scheinberg, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110210/
https://ncbi.nlm.nih.gov/pubmed/27680026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0177
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