Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size

The dynamics of HIV reservoir accumulation off antiretroviral therapy (ART) is underexplored. Levels of integrated HIV DNA in peripheral blood mononuclear cells (PBMCs) were longitudinally monitored before and after antiviral therapy. HIV integration increased over time in both elite controllers (EC...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Pinzone, Marilia Rita, Graf, Erin, Lynch, Lindsay, McLaughlin, Brigit, Hecht, Frederick M., Connors, Mark, Migueles, Stephen A., Hwang, Wei-Ting, Nunnari, Giuseppe, O'Doherty, Una
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110192/
https://ncbi.nlm.nih.gov/pubmed/27630237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00242-16
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