Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study

OBJECTIVE: To identify a cortical signature pattern of cortical thinning in familial Alzheimer disease (FAD) and assess its utility in detecting and tracking presymptomatic neurodegeneration. METHODS: We recruited 43 FAD mutation carriers—36 PSEN1, 7 APP (20 symptomatic, 23 presymptomatic)—and 42 he...

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Publicat a:Neurology
Autors principals: Weston, Philip S.J., Nicholas, Jennifer M., Lehmann, Manja, Ryan, Natalie S., Liang, Yuying, Macpherson, Kirsty, Modat, Marc, Rossor, Martin N., Schott, Jonathan M., Ourselin, Sebastien, Fox, Nick C.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109950/
https://ncbi.nlm.nih.gov/pubmed/27733562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003322
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