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Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions
K-Ras is the most frequently mutated oncogene in human cancers, but there are still no drugs that directly target it in the clinic. Recent studies utilizing dynamics information show promising results for selectively targeting mutant K-Ras. However, despite extensive characterization, the mechanisms...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5109477/ https://ncbi.nlm.nih.gov/pubmed/27845397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37012 |
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