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Oncogenic G12D mutation alters local conformations and dynamics of K-Ras
K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of its dynamics. Here, we present local changes in K-Ras structure, conformation and...
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| Опубликовано в: : | Sci Rep |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6692342/ https://ncbi.nlm.nih.gov/pubmed/31409810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48029-z |
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