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Molecular basis for cytoplasmic RNA surveillance by uridylation‐triggered decay in Drosophila

The posttranscriptional addition of nucleotides to the 3′ end of RNA regulates the maturation, function, and stability of RNA species in all domains of life. Here, we show that in flies, 3′ terminal RNA uridylation triggers the processive, 3′‐to‐5′ exoribonucleolytic decay via the RNase II/R enzyme...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Reimão‐Pinto, Madalena M, Manzenreither, Raphael A, Burkard, Thomas R, Sledz, Pawel, Jinek, Martin, Mechtler, Karl, Ameres, Stefan L
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109242/
https://ncbi.nlm.nih.gov/pubmed/27729457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695164
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