Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3′ Uridylated Intermediates Degraded by DIS3L2

Apoptosis is a tightly coordinated cell death program that damages mitochondria, DNA, proteins, and membrane lipids. Little is known about the fate of RNA as cells die. Here, we show that mRNAs, but not noncoding RNAs, are rapidly and globally degraded during apoptosis. mRNA decay is triggered early...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Thomas, Marshall P., Liu, Xing, Whangbo, Jennifer, McCrossan, Geoffrey, Sanborn, Keri B., Basar, Emre, Walch, Michael, Lieberman, Judy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862650/
https://ncbi.nlm.nih.gov/pubmed/25959823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.026
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