TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin

Expression of the TUSC2/FUS1 tumor suppressor gene in TUSC2 deficient EGFR wildtype lung cancer cells increased sensitivity to erlotinib. Microarray mRNA expression analysis of TUSC2 inducible lung cancer cells treated with erlotinib uncovered defects in the response to oxidative stress suggesting t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Xiaobo, Cao, Majidi, Mourad, Feng, Meng, Shao, Ruping, Wang, Jing, Zhao, Yang, Baladandayuthapani, Veerabhadran, Song, Juhee, Fang, Bingliang, Ji, Lin, Mehran, Reza, Roth, Jack A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109231/
https://ncbi.nlm.nih.gov/pubmed/27845352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35741
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