TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin

Expression of the TUSC2/FUS1 tumor suppressor gene in TUSC2 deficient EGFR wildtype lung cancer cells increased sensitivity to erlotinib. Microarray mRNA expression analysis of TUSC2 inducible lung cancer cells treated with erlotinib uncovered defects in the response to oxidative stress suggesting t...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Xiaobo, Cao, Majidi, Mourad, Feng, Meng, Shao, Ruping, Wang, Jing, Zhao, Yang, Baladandayuthapani, Veerabhadran, Song, Juhee, Fang, Bingliang, Ji, Lin, Mehran, Reza, Roth, Jack A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109231/
https://ncbi.nlm.nih.gov/pubmed/27845352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35741
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