Cav1.2 and Cav1.3 L‐type calcium channels independently control short‐ and long‐term sensitization to pain

KEY POINTS: L‐type calcium channels in the CNS exist as two subunit forming channels, Cav1.2 and Cav1.3, which are involved in short‐ and long‐term plasticity. We demonstrate that Cav1.3 but not Cav1.2 is essential for wind‐up. These results identify Cav1.3 as a key conductance responsible for short...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Radwani, Houda, Lopez‐Gonzalez, Maria José, Cattaert, Daniel, Roca‐Lapirot, Olivier, Dobremez, Eric, Bouali‐Benazzouz, Rabia, Eiríksdóttir, Emelía, Langel, Ülo, Favereaux, Alexandre, Errami, Mohammed, Landry, Marc, Fossat, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Neuroscience ‐ Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108908/
https://ncbi.nlm.nih.gov/pubmed/27231046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272725
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