Cav1.2 and Cav1.3 L‐type calcium channels independently control short‐ and long‐term sensitization to pain

KEY POINTS: L‐type calcium channels in the CNS exist as two subunit forming channels, Cav1.2 and Cav1.3, which are involved in short‐ and long‐term plasticity. We demonstrate that Cav1.3 but not Cav1.2 is essential for wind‐up. These results identify Cav1.3 as a key conductance responsible for short...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Physiol
Auteurs principaux: Radwani, Houda, Lopez‐Gonzalez, Maria José, Cattaert, Daniel, Roca‐Lapirot, Olivier, Dobremez, Eric, Bouali‐Benazzouz, Rabia, Eiríksdóttir, Emelía, Langel, Ülo, Favereaux, Alexandre, Errami, Mohammed, Landry, Marc, Fossat, Pascal
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Neuroscience ‐ Cellular/Molecular
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108908/
https://ncbi.nlm.nih.gov/pubmed/27231046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272725
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