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Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation
The BRAF kinase, within the mitogen activated protein kinase (MAPK) signaling pathway, harbors activating mutations in about half of melanomas and to a significant extent in many other cancers. A single valine to glutamic acid substitution at residue 600 (BRAF(V600E)) accounts for about 90% of these...
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| 出版年: | ACS Chem Biol |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5108658/ https://ncbi.nlm.nih.gov/pubmed/27571413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00529 |
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