Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons

Mutations in the MECP2 gene cause the neurodevelopmental disorder Rett syndrome (RTT). Previous studies have shown that altered MeCP2 levels result in aberrant neurite outgrowth and glutamatergic synapse formation. However, causal molecular mechanisms are not well understood since MeCP2 is known to...

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Veröffentlicht in:eLife
Hauptverfasser: Sampathkumar, Charanya, Wu, Yuan-Ju, Vadhvani, Mayur, Trimbuch, Thorsten, Eickholt, Britta, Rosenmund, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2016
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108590/
https://ncbi.nlm.nih.gov/pubmed/27782879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19374
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