High-throughput mapping of regulatory DNA

Quantifying the effects of cis-regulatory DNA on gene expression is a major challenge. Here, we present the multiplexed editing regulatory assay (MERA); a high-throughput CRISPR/Cas9-based approach that analyzes the functional impact of the regulatory genome in its native context. MERA tiles thousan...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Rajagopal, Nisha, Srinivasan, Sharanya, Kooshesh, Kameron, Guo, Yuchun, Edwards, Matthew D, Banerjee, Budhaditya, Syed, Tahin, Emons, Bart JM, Gifford, David K, Sherwood, Richard I
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108523/
https://ncbi.nlm.nih.gov/pubmed/26807528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3468
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