Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation

Our previous studies have demonstrated functional protein–protein interactions between cytochrome P450 (CYP) 3A and UDP-glucuronosyltransferase (UGT). However, the role of carbohydrate chains of UGTs in the interaction with CYP is not well understood. To address this issue, we examined whether CYP3A...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Pharmacol
Prif Awduron: Nakamura, Tatsuro, Yamaguchi, Naho, Miyauchi, Yuu, Takeda, Tomoki, Yamazoe, Yasushi, Nagata, Kiyoshi, Mackenzie, Peter I., Yamada, Hideyuki, Ishii, Yuji
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2016
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107996/
https://ncbi.nlm.nih.gov/pubmed/27895582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00427
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