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RNA sequence context effects measured in vitro predict in vivo protein binding and regulation
Many RNA binding proteins (RBPs) bind specific RNA sequence motifs, but only a small fraction (~15-40%) of RBP motif occurrences are occupied in vivo. To determine what contextual features discriminate between bound and unbound motifs, we performed an in vitro binding assay using 12,000 mouse RNA se...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5107313/ https://ncbi.nlm.nih.gov/pubmed/27720642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.08.035 |
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