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Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

Post-mortem investigations of human Alzheimer’s disease (AD) have largely failed to provide unequivocal evidence in support of the original amyloid cascade hypothesis, which postulated deposition of β-amyloid (Aβ) aggregates to be the cause of a demented state as well as inductive to tau neurofibril...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Koss, David J., Jones, Glynn, Cranston, Anna, Gardner, Heidi, Kanaan, Nicholas M., Platt, Bettina
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106509/
https://ncbi.nlm.nih.gov/pubmed/27770234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1632-3
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