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Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues

Understanding the genetic architecture of gene expression traits is key to elucidating the underlying mechanisms of complex traits. Here, for the first time, we perform a systematic survey of the heritability and the distribution of effect sizes across all representative tissues in the human body. W...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Wheeler, Heather E., Shah, Kaanan P., Brenner, Jonathon, Garcia, Tzintzuni, Aquino-Michaels, Keston, Cox, Nancy J., Nicolae, Dan L., Im, Hae Kyung
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106030/
https://ncbi.nlm.nih.gov/pubmed/27835642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006423
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