Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8(+) T Cell Activation In Vitro but Not in C57BL/6 Mice

Due to antigenic drift of influenza viruses, seasonal influenza vaccines need to be updated annually. These vaccines are based on predictions of strains likely to circulate in the next season. However, vaccine efficacy is greatly reduced in the case of a mismatch between circulating and vaccine stra...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Altenburg, Arwen F., van de Sandt, Carolien E., van Trierum, Stella E., De Gruyter, Heidi L. M., van Run, Peter R. W. A., Fouchier, Ron A. M., Roose, Kenny, Saelens, Xavier, Volz, Asisa, Sutter, Gerd, de Vries, Rory D., Rimmelzwaan, Guus F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105657/
https://ncbi.nlm.nih.gov/pubmed/27581985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01633-16
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