Structural assemblies of the di- and oligomeric G-protein coupled receptor TGR5 in live cells: an MFIS-FRET and integrative modelling study

TGR5 is the first identified bile acid-sensing G-protein coupled receptor, which has emerged as a potential therapeutic target for metabolic disorders. So far, structural and multimerization properties are largely unknown for TGR5. We used a combined strategy applying cellular biology, Multiparamete...

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Publicat a:Sci Rep
Autors principals: Greife, Annemarie, Felekyan, Suren, Ma, Qijun, Gertzen, Christoph G. W., Spomer, Lina, Dimura, Mykola, Peulen, Thomas O., Wöhler, Christina, Häussinger, Dieter, Gohlke, Holger, Keitel, Verena, Seidel, Claus A. M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105069/
https://ncbi.nlm.nih.gov/pubmed/27833095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36792
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