Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells

This study aimed to determine the reaction kinetics of the regioselective glucuronidation of diosmetin and chrysoeriol, two important methylated metabolites of luteolin, by human liver microsomes (HLMs) and uridine-5′-diphosphate glucuronosyltransferase (UGTs) enzymes. This study also investigated t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zeng, Xuejun, Shi, Jian, Zhao, Min, Chen, Qingwei, Wang, Liping, Jiang, Huangyu, Luo, Feifei, Zhu, Lijun, Lu, Linlin, Wang, Xinchun, Liu, Zhongqiu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104480/
https://ncbi.nlm.nih.gov/pubmed/27832172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166239
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