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Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells

This study aimed to determine the reaction kinetics of the regioselective glucuronidation of diosmetin and chrysoeriol, two important methylated metabolites of luteolin, by human liver microsomes (HLMs) and uridine-5′-diphosphate glucuronosyltransferase (UGTs) enzymes. This study also investigated t...

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Publicat a:PLoS One
Autors principals: Zeng, Xuejun, Shi, Jian, Zhao, Min, Chen, Qingwei, Wang, Liping, Jiang, Huangyu, Luo, Feifei, Zhu, Lijun, Lu, Linlin, Wang, Xinchun, Liu, Zhongqiu
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104480/
https://ncbi.nlm.nih.gov/pubmed/27832172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166239
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